He is well-connected to several Mumbai film families. He is the son of actor Sanjay Khan and the cousin of Fardeen Khan. His mother is Zarine Khan. He has three sisters: Suzanne Roshan, Simone Khan and Faraah Khan. His sister Suzanne is married to the well-known actor Hrithik Roshan. Zayed's childhood friend is Esha Deol. He is half Parsi and half Pathan.
He studied at Welham Boys' School, Dehradun and the Kodaikanal International School, Kodaikanal.
He married his longtime girlfriend Malaika Parekh on 20 November 2005,
Zayed debuted in the 2003 film Chura Liyaa Hai Tumne with actress Esha Deol. The film did not do well at the box office so it was flop. However, he rose to fame with Farah Khan's Main Hoon Na (2004), where he co-starred with Shah Rukh Khan and Amrita Rao. In that film he played a big-man-on-campus college student named Lucky. His next release Dus (2005) also did well.
He signed for an international touring stage show, "Rockstars".
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